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W J Pichler Selected Research

Drug Hypersensitivity (Drug Allergy)

11/2012Human leukocyte antigens (HLA) associated drug hypersensitivity: consequences of drug binding to HLA.
1/2012Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells.
1/2012Etiology and pathogenesis of adverse drug reactions.
4/2011In vitro diagnosis of T cell-mediated drug allergy.
3/2010In vitro detection of cytotoxic T and NK cells in peripheral blood of patients with various drug-induced skin diseases.
9/2009Fulminant liver failure after vancomycin in a sulfasalazine-induced DRESS syndrome: fatal recurrence after liver transplantation.
9/2009Drug-specific in vitro release of IL-2, IL-5, IL-13 and IFN-gamma in patients with delayed-type drug hypersensitivity.
2/2008CD69 upregulation on T cells as an in vitro marker for delayed-type drug hypersensitivity.
7/2007Delayed drug hypersensitivity reactions - new concepts.
11/2004Diagnosis of nonimmediate reactions to beta-lactam antibiotics.
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W J Pichler Research Topics

Disease

25Hypersensitivity (Allergy)
11/2013 - 01/2000
18Drug Hypersensitivity (Drug Allergy)
11/2012 - 01/2001
9Exanthema (Rash)
09/2009 - 04/2000
5Inflammation (Inflammations)
11/2009 - 11/2000
4Drug-Related Side Effects and Adverse Reactions
11/2013 - 10/2000
4Seasonal Allergic Rhinitis (Hay Fever)
02/2012 - 05/2001
4Eosinophilia
09/2009 - 10/2000
4Anaphylaxis (Anaphylactic Shock)
06/2008 - 11/2000
4Infections
12/2001 - 05/2000
3Urticaria (Hives)
01/2013 - 04/2002
3Skin Diseases (Skin Disease)
03/2010 - 11/2000
3Delayed Hypersensitivity (Hypersensitivity, Type IV)
02/2010 - 01/2006
3Acute Generalized Exanthematous Pustulosis
01/2006 - 06/2001
3Asthma (Bronchial Asthma)
12/2002 - 04/2001
3Psoriasis (Pustulosis Palmaris et Plantaris)
06/2001 - 12/2000
3Drug Eruptions (Drug Eruption)
01/2001 - 10/2000
2Chronic Urticaria
12/2002 - 04/2002
2Atopic Dermatitis (Atopic Eczema)
06/2001 - 11/2000
2Allergic Contact Dermatitis
03/2001 - 01/2000
1Renal Insufficiency (Renal Failure)
11/2013
1Cicatrix (Scar)
11/2013
1Stevens-Johnson Syndrome (Lyell's Syndrome)
09/2013
1Allergic Rhinitis
11/2009
1Hepatitis
09/2009
1Drug Hypersensitivity Syndrome
09/2009
1Arthritis (Polyarthritis)
09/2009
1Necrosis
09/2009
1Acute Liver Failure (Fulminant Hepatic Failure)
09/2009
1Fever (Fevers)
01/2006
1Dust Mite Allergy
02/2004
1Food Hypersensitivity (Food Allergy)
05/2002
1Pruritus (Itching)
04/2002
1Chronic Hepatitis (Chronic Active Hepatitis)
12/2001
1Human Influenza (Influenza)
12/2001

Drug/Important Bio-Agent (IBA)

29Pharmaceutical PreparationsIBA
09/2013 - 06/2000
6AllergensIBA
02/2012 - 04/2001
5Interleukin-5 (Interleukin 5)IBA
09/2009 - 07/2000
4Anti-Bacterial Agents (Antibiotics)IBA
01/2012 - 01/2006
4Contrast MediaIBA
02/2010 - 01/2000
4CytokinesIBA
09/2009 - 03/2003
4Granzymes (Granzyme)IBA
06/2001 - 06/2000
4PerforinIBA
06/2001 - 06/2000
3ChemokinesIBA
09/2009 - 12/2000
3Immunoglobulin E (IgE)IBA
07/2007 - 05/2002
3AntigensIBA
11/2002 - 12/2001
3Proteins (Proteins, Gene)FDA Link
05/2002 - 03/2001
2Allopurinol (Remid)FDA LinkGeneric
11/2013 - 11/2012
2HLA-B Antigens (HLA-B)IBA
11/2013 - 11/2012
2Biological ProductsIBA
11/2010 - 08/2006
2Penicillins (Penicillin)FDA Link
11/2010 - 04/2000
2Interleukin-2 (IL2)IBA
09/2009 - 01/2000
2Adrenal Cortex Hormones (Corticosteroids)IBA
01/2006 - 11/2000
2Histamine Antagonists (Antihistamines)IBA
01/2006 - 04/2002
2beta-LactamsIBA
11/2004 - 08/2004
2beta Lactam AntibioticsIBA
10/2003 - 01/2001
2Peptides (Polypeptides)IBA
11/2002 - 12/2001
2HLA-DR Antigens (HLA-DR)IBA
09/2001 - 01/2001
2SulfamethoxazoleFDA LinkGeneric
05/2001 - 02/2001
2Hydroxylamine (Hydroxylamine Hydrochloride)IBA
02/2001 - 06/2000
2Interleukin-12 (IL 12)IBA
11/2000 - 01/2000
1Oxypurinol (Oxipurinol)IBA
11/2013
1Intravenous Immunoglobulins (IVIG)FDA Link
01/2013
1ElementsIBA
11/2012
1HLA Antigens (Human Leukocyte Antigens)IBA
11/2012
1Immunoglobulin G (IgG)IBA
02/2012
1Anticonvulsants (Antiepileptic Drugs)IBA
01/2012
1InsulinsIBA
11/2010
1SulfonamidesIBA
11/2010
1Nitric Oxide (Nitrogen Monoxide)FDA Link
11/2009
1Sulfasalazine (Azulfidine)FDA LinkGeneric
09/2009
1VancomycinFDA LinkGeneric
09/2009
1Interleukin-13IBA
09/2009
1petasinIBA
01/2006
1QuinolonesIBA
01/2006
1NorfloxacinFDA Link
01/2006
1acrivastine (Semprex)FDA Link
01/2006
1Ciprofloxacin (Cipro)FDA LinkGeneric
01/2006
1Hydrocortisone (Cortisol)FDA LinkGeneric
01/2006
1Moxifloxacin (Avelox)FDA Link
01/2006
1Prednisolone (Predate)FDA LinkGeneric
01/2006
1SteroidsIBA
01/2006
1Ze 339IBA
01/2006
1Anti-Allergic Agents (Antiallergic Agents)IBA
01/2006
1Butyrates (Butyrate)IBA
01/2006
1Carbamazepine (Tegretol)FDA LinkGeneric
03/2003
1Leukotriene D4IBA
12/2002
1LeukotrienesIBA
12/2002
1Leukotriene E4IBA
12/2002
1Therapeutic UsesIBA
12/2002
1zafirlukast (Accolate)FDA LinkGeneric
12/2002
1Leukotriene C4IBA
12/2002
1Leukotriene Antagonists (Leukotriene Receptor Antagonists)IBA
12/2002
1fexofenadine (Allegra)FDA LinkGeneric
04/2002
1Terfenadine (Seldane)IBA
04/2002
1Celecoxib (Celebrex)FDA Link
03/2002
1Hepatitis B Surface Antigens (HBsAg)FDA Link
12/2001
1EpitopesIBA
12/2001
1Hemagglutinins (Hemagglutinin)IBA
12/2001

Therapy/Procedure

4Immunotherapy
02/2012 - 04/2001
1Liver Transplantation
09/2009